International Scientific Literature
devoted to PRP treatment of knee arthritis

You will find in this bibliography the list of the main international publications on PRP therapy in degenerative (arthritis) injuries of the knee.
These articles from international scientific journals are in English. They allowed me to be “up to date”, as a result of knowing what was best in the world for the care of arthrosis knees medically today.

This bibliography is constantly updated.

In practice, it brings together in a non-exhaustive manner all that is essential to know in the field to any doctor, rheumatologist, sports doctor or orthopedic surgeon interested in this activity.

Thus, by the analysis of this literature listed in this bibliography and by the collaboration of Professor Guy Magalon (plastic and reconstructive surgery), and Doctor Jérémy Magalon (service of the Cell Culture and Therapy Unit of the ‘Conception Hospital’, PRP injection protocols for knee arthritis have been established and implemented at the Mediterranean Institute of Regenerative Medicine.

Cellules Souches Bibliographie
Docteur Jérémy MAGALON
Bibliographie Cellules souches
Professeur Guy MAGALON
  1. A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature.
  2. Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial.
  3. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation.
  4. Analysis of Platelet-Rich Plasma Extraction: Variations in Platelet and Blood Components Between 4 Common Commercial Kits.
  5. A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma.
  6. A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis.
  7. A systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty.
  8. Are Subchondral Intraosseous Injections Effective and Safe for the Treatment of Knee Osteoarthritis? A Systematic Review.   
  9. Augmentation Techniques for Meniscus Repair.
  10. Biologic Therapies for the Treatment of Knee Osteoarthritis.
  11. Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 3: Articular Cartilage.
  12. Bone Marrow Cellular Therapies: Novel Therapy for Knee Osteoarthritis.
  13. Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.
  14. Cellular therapy injections in today’s orthopedic market: A social media analysis. 
  15. Cellular Therapies in Orthopedics: Where Are We?
  16. Characterization and comparison of 5 platelet-rich plasma preparations in a single-donor model.
  17. Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up : a randomised controlled trial. 
  18. Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis
  19. Clinical applications of platelet-rich plasma in patellar tendinopathy.
  20. Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis.
  21. Clinical outcome of autologous bone marrow aspirates concentrate (BMAC) injection in degenerative arthritis of the knee.
  22. Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee.
  23. Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study. 
  24. Combined Bone Marrow Aspirate and Platelet-Rich Plasma for Cartilage Repair: Two-Year Clinical Results.
  25. Commercial Separation Systems Designed for Preparation of Platelet-Rich Plasma Yield Differences in Cellular Composition.
  26. Comparative release of growth factors from PRP, PRF, and advanced-PRF.
  27. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis.
  28. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. 
  29. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. 
  30. Comparison of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) versus Durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: a randomized controlled trial.
  31. Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair.
  32. Current Clinical Recommendations for Use of Platelet-Rich Plasma.
  33. Current concepts in intraosseous Platelet-Rich Plasma injections for knee osteoarthritis. 
  34. Current perspectives in mesenchymal stem cell therapies for osteoarthritis.
  35. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices.  
  36. Does Intra-articular Platelet-Rich Plasma Injection Provide Clinically Superior Outcomes Compared With Other Therapies in the Treatment of Knee Osteoarthritis ? A systematic review of overlapping Meta-Analyses.
  37. Does intraarticular PRP injection improve function, pain and quality of life in patients with OA of knee? Case control study of 50 patients.
  38. Early Clinical Outcomes of Intra-Articular Injections of Bone Marrow Aspirate Concentrate for the Treatment of Early Osteoarthritis of the Hip and Knee : A Cohort Study.
  39. Editorial Commentary: Platelet-Rich Plasma for Knee Osteoarthritis: A « Novel » and Effective Symptomatic Approach.
  40. Effectiveness and relevant factors of platelet-rich plasma treatment in managing plantar fasciitis: A systematic review.
  41. Effectiveness of mesenchymal stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment of effective regenerative rehabilitation. 
  42. Effectiveness of Platelet-Rich Plasma in the Management of Knee Osteoarthritis in a Rural Clinic.
  43. Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial.
  44. Effects of platelet-rich plasma in the treatment of plantar fasciitis: A meta-analysis of randomized controlled trials.
  45. Effects of platelet-rich plasma on the clinical outcomes and cartilage thickness in patients with knee osteoarthritis.
  46. Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis.
  47. Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review.
  48. Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials.
  49. Efficacy of platelet-rich plasma injections in pain associated with chronic tendinopathy: A systematic review. 
  50. Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. 
  51. Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis.
  52. Efficiency of platelet-rich plasma therapy in knee osteoarthritis does not depend on level of cartilage damage.
  53. Evidence and recommendations for use of intra-articular injections for knee osteoarthritis.
  54. Formulation and storage of platelet-rich plasma homemade product.
  55. Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis.
  56. Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation.
  57. Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections.
  58. Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis.
  59. Impact of Platelet-Rich Plasma Use on Pain in Orthopaedic Surgery: A Systematic Review and Meta-analysis.
  60. Improvising PRP for use in osteoarthritis knee- upcoming trends and futuristic view.
  61. Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells.
  62. Intra-articular and extra-articular platelet-rich plasma injections for knee osteoarthritis: A 26-week, single-arm, pilot feasibility study.
  63. Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis.
  64. Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis.
  65. Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis
  66. Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo Controlled Clinical Trial.
  67. Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial.
  68. Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A 2-Year Follow-up Study.
  69. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study.
  70. Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis : A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial.
  71. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis.
  72. Intra-articular platelet-rich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations.
  73. Intra-articular Platelet-Rich Plasma Injections for Treating Knee Pain Associated with Articular Cartilage and Degenerative Meniscal Lesions.
  74. Intra-articular treatment options for knee osteoarthritis.
  75. Intraosseous Infiltration of Platelet-Rich Plasma for Severe Hip Osteoarthritis.
  76. Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis.
  77. Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trial.
  78. Knee Articular Cartilage Repair and Restoration Techniques: A Review of the Literature.
  79. Lancet Commission: Stem cells and regenerative medicine.
  80. Leukocyte-poor PRP application for the treatment of knee osteoarthritis.
  81. Leukocyte-rich PRP for knee osteoarthritis: Current concepts.
  82. Management of knee articular cartilage injuries in athletes: chondroprotection, chondrofacilitation, and resurfacing.
  83. Meta-analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients with Knee Osteoarthritis.  
  84. Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence.
  85. Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells.
  86. Need for Proper Classification of PRP : Letter to the Editor
  87. Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference.
  88. Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee. 
  89. Plasma enrichi en plaquettes en pathologie musculosquelettique.
  90. Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems.
  91. Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner. 
  92. Platelet rich plasma and knee surgery. 
  93. Platelet-Rich Plasma and the Knee-Applications in Orthopedic Surgery. 
  94. Platelet-rich plasma combined with allograft to treat osteochondritis dissecans of the knee: a case report.
  95. Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy – a systematic review.
  96. Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Review.
  97. Platelet-Rich Plasma Injections as a Treatment for Refractory Patellar Tendinosis: A Meta-Analysis of Randomised Trials.
  98. Platelet-rich plasma in osteoarthritis treatment: review of current evidence
  99. Platelet Rich Plasma in Orthopaedics and Sport Medecine.
  100. Platelet-rich plasma in tendon-related disorders: results and indications.
  101. Platelet-rich plasma in the management of articular cartilage pathology: a systematic review
  102. Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis.
  103. Platelet-rich plasma preparation using three devices: implications for platelet activation and platelet growth factor release.
  104. Platelet-rich plasma products in sports medicine.
  105. Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis.
  106. Platelet-rich plasma: where are we now and where are we going?
  107. Platelet-rich therapies for musculoskeletal soft tissue injuries. The Cochrane database of systematic reviews.
  108. Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis.
  109. Rehabilitation following regenerative medicine treatment for knee osteoarthritis-current concept review.
  110. Role of mesenchymal stem cells in meniscal repair.
  111. Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial.
  112. Single Injection of High Volume of Autologous Pure PRP Provides a Significant Improvement in Knee Osteoarthritis: A Prospective Routine Care Study.
  113. Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee.
  114. Should Platelet-Rich Plasma or Stem Cell Therapy Be Used to Treat Osteoarthritis?
  115. Stem Cells for the Treatment of Knee Osteoarthritis: A Comprehensive Review.
  116. Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee.
  117. The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis.
  118. The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?
  119. The Current Status of Cell-Based Therapies for Primary Knee Osteoarthritis.
  120. The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-analysis With Bias Assessment.
  121. The effect of corticosteroid versus platelet-rich plasma injection therapies for the management of lateral epicondylitis: A systematic review.
  122. The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy.
  123. The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Clinical Trials.
  124. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis.
  125. The effects of platelet-rich plasma in the treatment of large-joint osteoarthritis: a systematic review.
  126. The effects of platelet-rich plasma on reducing blood loss after total knee arthroplasty: A systematic review and meta-analysis.
  127. The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee.
  128. The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis.
  129. The role of growth factors in cartilage repair.
  130. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.
  131. The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis. 
  132. The use of PRP injections in the management of knee osteoarthritis.
  133. The use of ultrasound-guided platelet-rich plasma injections in the treatment of hip osteoarthritis: a systematic review of the literature.
  134. Treating Severe Knee Osteoarthritis with Combination of Intra-Osseous and Intra-Articular Infiltrations of Platelet-Rich Plasma: An Observational Study.
  135. Treatment of Early Hip Osteoarthritis: Ultrasound-Guided Platelet Rich Plasma versus Hyaluronic Acid Injections in a Randomized Clinical Trial.
  136. Treatment of knee chondropathy with platelet rich plasma. Preliminary results at 6 months of follow-up with only one injection.
  137. Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial. 
  138. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip.
  139. Use of Platelet-Rich Plasma in Intra-Articular Knee Injections for Osteoarthritis : a systemic review.
  140. Use of platelet-rich plasma in regenerative medicine: technical tools for correct quality control.
  141. Variability of the Composition of Growth Factors and Cytokines in Platelet-Rich Plasma From the Knee With Osteoarthritis.
  142. Volumetric findings of MRI after platelet rich plasma injection in knee osteoarthritis (A randomized clinical trial)-